Platycodin D2( —— )

Catalog No. M29216 CAS No. 66663-90-9

Platycodin D2 , a less hemolytic saponin, can improve specific cellular and humoral responses to hepatitis B surface antigen in mice, it could be safely used as adjuvant eliciting Th1 and Th2 immune responses.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

Platycodin D2
Note

Research use only, not for human use.
Brief Description

Platycodin D2 , a less hemolytic saponin, can improve specific cellular and humoral responses to hepatitis B surface antigen in mice, it could be safely used as adjuvant eliciting Th1 and Th2 immune responses.
Description

Platycodin D2 , a less hemolytic saponin, can improve specific cellular and humoral responses to hepatitis B surface antigen in mice, it could be safely used as adjuvant eliciting Th1 and Th2 immune responses.(In Vitro):Platycodin D2 exhibited significant inhibition on the proliferation of five kinds of cultured human tumor cell lines(ED50: ca. 4 - 18 microg/mL), i. e., A549 (non-small cell lung), SK-OV-3 (ovary), SK-MEL-2 (melanoma), XF498 (central nerve system) and HCT-15 (colon), in vitro.(In Vivo):Platycodin D2 significantly increased the concanavalin A (Con A)-, lipopolysaccharide (LPS)-, and HBsAg-induced splenocyte proliferation in HBsAg-immunized mice (P<0.05, P<0.01, and P<0.001, resp.). HBsAg-specific IgG, IgG1, IgG2a, and IgG2b antibody titers in the serum were also markedly enhanced by Platycodin D2 compared to the HBsAg control group (P<0.01 or P<0.001). Moreover, Platycodin D2 significantly promoted the production of Th1 (IL-2 and IFN-gamma) and Th2 (IL-4 and IL-10) cytokines from splenocytes in the HBsAg-immunized mice (P<0.001). The adjuvant potential of Platycodin D2 on splenocyte proliferation, serum HBsAg-specific IgG2a and IgG2b antibody response, as well as Th1-cytokine secretion from splenocytes in the HBsAg-immunized mice was higher than that of Alum.
In Vitro

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In Vivo

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Synonyms

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Pathway

Apoptosis
Target

IL Receptor
Recptor

IL Receptor
Research Area

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Indication

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Chemical Information

CAS Number

66663-90-9
Formula Weight

1387.476
Molecular Formula

C63H102O33
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (72.07 mM)
SMILES

C[C@@H]1O[C@@H](O[C@@H]2[C@@H](O)[C@@H](O)CO[C@H]2OC(=O)[C@]23CCC(C)(C)C[C@H]2C2=CC[C@@H]4[C@@]5(C)C[C@H](O)[C@H](O[C@@H]6O[C@H](CO)[C@@H](O)[C@H](O[C@@H]7O[C@H](CO)[C@@H](O)[C@H](O)[C@H]7O)[C@H]6O)C(CO)(CO)[C@@H]5CC[C@@]4(C)[C@]2(C)C[C@H]3O)[C@H](O)[C@H](O)[C@H]1O[C@@H]1OC[C@@H](O)[C@H](O[C@@H]2OC[C@](O)(CO)[C@H]2O)[C@H]1O
Chemical Name

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